y2016m11b10
20161124081000
assa
nadine@assaf.org.za
assa
South African Journal of Science
S. Afr. J. Sci
0038-2353
1996-7489
11242016
Volume 112
Number 11/12
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean
Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean
Elisabeth K.
Olsen
Department of Chemistry, University of Cape Town, Cape Town, South Africa
MRC/NHLS Molecular Mycobacteriology Research Unit, University of Cape Town, Cape Town, South Africa
Christopher K.
de Cerf
Department of Chemistry, University of Cape Town, Cape Town, South Africa
Godwin A.
Dziwornu
Department of Chemistry, University of Cape Town, Cape Town, South Africa
Eleonora
Puccinelli
Department of Zoology and Entomology, Rhodes University, Grahamstown, South Africa
Department of Oceanography, University of Cape Town, Cape Town, South Africa
Isabelle J.
Ansorge
Department of Oceanography, University of Cape Town, Cape Town, South Africa
Marine Research (Ma-Re) Institute, University of Cape Town, Cape Town, South Africa
Toufiek
Samaai
Marine Research (Ma-Re) Institute, University of Cape Town, Cape Town, South Africa
Oceans and Coasts Research, Department of Environmental Affairs, Cape Town, South Africa
Laura M.K.
Dingle
Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa
Adrienne L.
Edkins
http://orcid.org/0000-0002-3615-6651
Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa
Suthananda N.
Sunassee
http://orcid.org/0000-0002-5014-7110
Department of Chemistry, University of Cape Town, Cape Town, South Africa
Marine Research (Ma-Re) Institute, University of Cape Town, Cape Town, South Africa
MRC Drug Discovery and Development Research Unit, University of Cape Town, Cape Town, South Africa
Abstract
Over the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean.
11242016
http://creativecommons.org/licenses/by/2.5/za/
http://creativecommons.org/licenses/by/2.5/za/
10.17159/sajs.2016/20160202
20161124081000
http://sajs.co.za/cytotoxic-activity-marine-sponge-extracts-sub-antarctic-islands-and-southern-ocean/elisabeth-k-olsen-christopher-k-de-cerf-godwin-dziwornu-eleonora-puccinelli-isabelle-j-ansorge
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf
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http://sajs.co.za/sites/default/files/publications/pdf/SAJS-112-11-12-Olsen_ResearchLetter.pdf